Cape Coast Castle, 150 kilometres (90 miles) from the capital Accra, is a major magnet for those visiting The white-washed fort lined with cannons was one of dozens of prisons studding the Atlantic coast where slaves were held before their journey to the New World.
A string of prominent African-Americans have headed to the site this year to mark the anniversary since the first slave landing in 1619.
Ghana, one of the continent's most stable democracies, has long pitched itself as a destination for African-Americans to explore their heritage and even settle permanently. In 2009 President Barack Obama visited with his family and paid homage at the Cape Coast Castle.
Story for AFP, Words by Kent Mensah